Brain-Derived Neurotrophic Factor (BDNF) Genomic Variants and Salivary Progesterone Levels in Female Patients with a History of Idiopathic Scoliosis: An Historical Cross-Sectional Study

Purpose: Adolescent idiopathic scoliosis is a condition characterized by three-dimensional curvature of the spine. However, in addition to spinal curvature, it has also been reported that patients with can display other abnormal physiologic parameters, such as hormone imbalances, genetic variants, and micronutrient deficiencies. The present study evaluated salivary progesterone levels, well results brain-derived neu-rotrophic factor (BDNF) genomic testing, from historical cohort seeking treatment at single integrative medicine clinic. Method: A group female history adolescent was compared non-scoliosis patients. Results: Salivary lev-els were 41% higher (P < 0.05), while 71% positive for BDNF func-tional 19% 0.05). These unchanged regardless menstrual status. Conclusion: suggest potential relationship between progesterone, BDNF, among Prospective studies are needed data extrapolation. current warrants further investigation.